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Today only two ethionamide products are quality-assured; one is prequalified by who macleods and pfizer has the marketing license for ethionamide in the us and canada.

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The crystal structure formed between InhA isolated from M. tuberculosis and INA indicated that INA binds to InhA in a competitive fashion with NADH ( Figure 7 ).and mutations within the NADH-binding region of InhA confer isoniazid resistance among clinical isolates.

inhA gene. Thus.in common with isoniazid.resistance is often associated with mutations in the inhA gene but.surprisingly.complete cross-resistance to isoniazid does not develop and partial cross-resistance is uncommon. Also in common with isoniazid.these agents are prodrugs that require activation by an enzyme encoded by the ethA locus but less than half the mutations conferring resistance to this agent occur in this locus.

Common side effects may include. nausea.vomiting.diarrhea. stomach pain.loss of appetite. increased salivation.metallic taste in your mouth. blisters or ulcers in your mouth.red or swollen gums.trouble swallowing. headache.dizziness. or drowsiness.depressed mood.restless feeling.

If you think there has been an overdose.call your poison control center or get medical care right away. Be ready to tell or show what was taken.how much.and when it happened.

Ethionamide is generally bacteriostatic at the doses that can be achieved in humans. Since its action is somewhat similar to isoniazid’s.and the latter appears to have AUC/MIC as the primary pharmacodynamically linked variable.perhaps that also is true of ethionamide.

FDA pregnancy category chlomid nolvadex supplier. C. It is not known whether ethionamide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

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